The Science Behind Sip2Sleep®: Clinically Proven Results

At Sip2Sleep®, we’re not just about natural ingredients; we’re about scientifically validated results. Our latest observational study in July 2023 underscores the effectiveness of Sip2Sleep® in enhancing sleep quality and overall well-being.

Key Findings:

  • Improved Sleep Quality: Participants experienced an average increase of 1.38 points on a 10-point sleep quality scale, a significant improvement when using Sip2Sleep® (p < 0.001).
  • Enhanced Daytime Alertness: Users reported an average increase of 1.47 points in daytime alertness, indicating a notable enhancement in daily functioning (p < 0.001).
  • Reduced Insomnia Severity: The study revealed a decrease in the Insomnia Severity Index (ISI) scores from 17.4 to 13.4, demonstrating Sip2Sleep®’s effectiveness in alleviating insomnia symptoms.
  • Anxiety Reduction: Participants saw a reduction in their anxiety levels, with average scores decreasing from 8.3 to 5.88.

Diverse Demographic Impact: This study encompassed a broad range of adults, showing that Sip2Sleep® is effective across various demographics in improving sleep and reducing anxiety.

Our commitment to science and your sleep goes beyond just natural ingredients. Sip2Sleep® is backed by research and real results, ensuring that you enjoy a restful night and a more vibrant day. Experience the difference that clinically proven sleep support can make.

Sip2Sleep® uses a proprietary formula of Montmorency tart cherry extract and Venetron®. Researchers at Louisiana State University presented data in 2018 showing that drinking Montmorency tart cherry juice just twice a day for two weeks helped increase total sleep time by nearly 90 minutes among older adults with insomnia.

Tart Cherry Extract

Montmorency tart cherry is a special kind of cherry with surprising benefits for insomnia. Did you know?

  • Montmorency tart cherries provide a natural source of melatonin
  • The ruby red pigments in this specific cherry are proanthocyanidins, natural compounds that help increase the brain availability of tryptophan—an essential amino acid and precursor to the natural sleep aid serotonin
  • Proanthocyanidins inhibit an enzyme (indoleamine 2,3 dioxygenase) that degrades tryptophan, a known predictor of insomnia
  • The minimization of tryptophan degradation may allow tryptophan to work more effectively in the body while increasing bioavailability for serotonin synthesis, leading to a positive effect on sleep while improving mood and decreasing inflammation


    Venetron® is a patented, purified, powdered extract derived from the Rafuma leaf, Apocynum venetum, which is a safe botanical alternative to St. John’s Wort. It helps insomnia by:

    • Not affecting the CYP3A pathway in the liver that many OTC natural substances (St. John’s Wort) and medications can impact. This means it does not increase the risk of side effects and other drug interaction
    • Containing bioactive flavonoids
    • Supporting serotonin concentrations in clinical trials by reducing the degradation of serotonin in the blood and brain, thus helping sleep and improving mood
    • Producing a calming effect by acting on the GABA-ergic system